Molecular Beacon Patents and Patent Applications

You can download the Patents and Patent Applications pdf-document to view a complete list of countries in which patent applications are filed and to view a complete list of countries in which patents are issued.

Patent and Patent Applications

Hybridization Probes for Nucleic Acid Detection, Universal Stems, Methods and Kits
(Filed in Australia, Canada, Europe and Japan)

Download European patent EP0728218
Detectably Labeled Dual Conformation Oligonucleotide Probes, Assays and Kits
(Filed in Australia, Canada, Europe, Japan and the United States)

Download US patent US05925517

Download US patent US06103476

Download European patent EP0745690
Nucleic Acid Detection Probes Having Non-FRET Fluorescence Quenching
and Kits and Assays Including Such Probes
(Filed in Australia, Canada, Europe, Japan and the United States)

Download US patent US06150097

Download European patent EP0892808
Non-Competitive Co-Amplification Methods
(Filed in Australia, Canada, Japan and the United States)

Download US patent US06461817
Wavelength-Shifting Probes and Primers and Their Use in Assays and Kits
(Filed in Australia, Canada, Europe, Japan and the United States)

Download US patent US06037130

Download European patent EP1100971
Assays for Short Sequence Variants
(Filed in Australia, Canada, Europe, Japan and the United States)

Download US patent US7662550

Download European patent EP1230387
Homogenous Multiplex Screening Assays and Kits
(Filed in Australia, Canada, China, Europe, Japan and the United States)

Download US patent US07385043

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Recent Publications from Our Group

In the November 23, 2011 issue of Cell, using our unique single-molecule imaging approach, we describe circumstances under which splicing is uncoupled from transcription. An interview conducted by Cell's editorial staff with Sanjay Tyagi about this work can be listened to at www.cell.com/../paperclip.mp3

Vargas DY, Shah K, Batish M, Levandoski M, Sinha S, Marras SAE, Schedl P, Tyagi S (2011) Single-molecule imaging of transcriptionally coupled and uncoupled splicing Cell 147, 1054-1065.

We describe a protocol for a novel method that utilizes single labeled Fluorescent In-situ Hybridization probes to image individual mRNA molecules

Batish M, Raj A, and Tyagi S (2011) Single Molecule Imaging of RNA In Situ. Methods in Molecular Biology 714, 3-11.

In collaboration with Diana Bratu and Irina Catrina at Hunter College in New York City, we published on the design parameters and applications of Locked Nucleic Acid (LNA) based molecular beacon probes to detect RNA in live cells

Bratu DP, Catrina IE, and Marras SAE (2011) Tiny molecular beacons for in vivo mRNA detection. Methods in Molecular Biology 714, 141-157.